Calcitonin blood testSerum calcitonin
The calcitonin blood test measures the level of the hormone calcitonin in the blood.
How the Test is Performed
Blood sample is needed
Venipuncture is the collection of blood from a vein. It is most often done for laboratory testing.
How to Prepare for the Test
There is usually no special preparation needed.
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. This soon goes away.
Why the Test is Performed
Calcitonin is a hormone produced in C cells of the thyroid gland. The thyroid gland is located inside the front of your lower neck. Calcitonin helps control the breakdown and rebuilding of bone.
A common reason to have the test is if you have had surgery to remove a thyroid tumor called medullary cancer. The test allows your health care provider to evaluate if the tumor has spread (metastasized) or has come back (tumor recurrence).
Your provider may also order a calcitonin test when you have symptoms of medullary cancer of the thyroid or multiple endocrine neoplasia (MEN) syndrome, or a family history of these conditions. Calcitonin may also be higher in other tumors, such as:
Medullary cancer of the thyroid
Medullary carcinoma of the thyroid is cancer of the thyroid gland that starts in cells that release a hormone called calcitonin. These cells are cal...
Multiple endocrine neoplasia (MEN)
Multiple endocrine neoplasia (MEN) type I is a disease in which one or more of the endocrine glands are overactive or forms a tumor. It is passed do...
- Insulinoma (tumor in the pancreas that produces too much insulin)
- Lung cancer
- VIPoma (cancer that usually grows from islet cells in the pancreas)
A normal value is less than 10 pg/mL.
Women and men can have different normal values, with men having higher values.
Sometimes, calcitonin in the blood is checked several times after you are given a shot (injection) of a special medicine that stimulates calcitonin production.
You will need this extra test if your baseline calcitonin is normal, but your provider suspects you have medullary cancer of the thyroid.
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different specimens. Talk to your provider about the meaning of your specific test results.
What Abnormal Results Mean
A higher-than-normal level may indicate:
- Lung cancer
- Medullary cancer of thyroid (most common)
Higher-than-normal levels of calcitonin can also occur in people with kidney disease, smokers, and higher body weight. Also, it increases when taking certain medicines to stop stomach acid production.
Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight, but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Bringhurst FR, Demay MB, Kronenberg HM. Hormones and disorders of mineral metabolism. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 13th ed. Philadelphia, PA: Elsevier; 2016:chap 28.
Chernecky CC, Berger BJ. Calcitonin (thyrocalcitonin) - serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:276-277.
Findlay DM, Sexton PM, Martin TJ. Calcitonin. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 58.
Review Date: 5/7/2017
Reviewed By: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.